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| Air
Pollution And Human Health |
The term Polycyclic Aromatic Hydrocarbons
(PAH's) refer to a large group of organic compounds widely distributed in the
atmosphere, whose molecular structure contains two or more aromatic rings fused
together. They are mainly formed during the incomplete burning of coal, oil and
gas, garbage and tobacco. Because of their low vapour pressure, some PAH's are
present both in the form of gases as well as associated with particles. The lighter
PAH's such as phenanthrene, are found exclusively in the gas phase, the heavier
PAH's such as Benzo (a ) pyrene are almost totally absorbed
into particles. PAH's are relatively insoluble in water but dissolve in fats and
oils.
Health
Effects of PAH
Humans are always
exposed to environmental mixture of PAH's. Population exposed to high concentrations
of PAH mixture depict an increased incidence of tumours. Lung cancer is obviously
linked to PAH's through inhaled air. Irrespective of their physical properties
and initial routes of exposure, the tumor inducing effects of carcinogenic PAH's
depend upon their conversion in the body into compounds which, unlike parent substances
are capable of reacting with and damaging the genetic material (DNA) in the nuclei
of cells, thus defined as gen-otoxic carcinogens.
| Classification of Selected PAH's According to Carcinogencity (IARC, 1987) Classification PAH Compound IARC Group 2 A Benzo(a ) pyerene 'Probably Carcinogenic Benzo (a ) anthracene to humans' Dibenz (ah) anthracene IARC Group 2B Benzo ( b) fluoranthene 'Possibly carcinogenic Benzo (k) fluoranthene to humans' Indeno (123 cd) pyrene IARC Group 3 Benzo (glin) perylene 'not classifiable’ Chrysene, Coronene, Fluorene, Anthrace,Dibenzanthracenne, |
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